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Infection ; 48(5): 681-686, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-232706

ABSTRACT

INTRODUCTION: Data on people living with human immunodeficiency virus (PLWH) in the current SARS-CoV-2 pandemic are still scarce. This case series of 33 PLWH patients with COVID-19 reveals symptoms and outcome in this special population. METHODS: Retrospective analysis of anonymized data including age, gender, HIV-associated parameters, symptoms, and outcome. RESULTS: Three out of 32 patients with documented outcomes died (9%). 91% of the patients recovered and 76% have been classified as mild cases. All patients were on antiretroviral treatment, of them 22 on tenofovir-containing regimen and 4 on the protease inhibitor darunavir. CONCLUSIONS: This preliminary case series does not support excess morbidity and mortality among symptomatic COVID-19 PLWH and with viral suppression on ART. SARS-CoV-2 infections may occur during boosted darunavir-based and/or on tenofovir-containing ART.


Subject(s)
Betacoronavirus/pathogenicity , Coronavirus Infections/virology , Darunavir/therapeutic use , HIV Infections/virology , HIV/pathogenicity , Pneumonia, Viral/virology , Tenofovir/therapeutic use , Adult , Antiretroviral Therapy, Highly Active , Betacoronavirus/drug effects , Betacoronavirus/immunology , COVID-19 , Coinfection , Coronavirus Infections/drug therapy , Coronavirus Infections/mortality , Coronavirus Infections/pathology , Female , HIV/drug effects , HIV/immunology , HIV Infections/drug therapy , HIV Infections/mortality , HIV Infections/pathology , Humans , Male , Middle Aged , Pandemics , Pneumonia, Viral/drug therapy , Pneumonia, Viral/mortality , Pneumonia, Viral/pathology , Retrospective Studies , SARS-CoV-2 , Severity of Illness Index , Survival Analysis , Viral Load/drug effects
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